X0 is “cholera”, from the title of Gabriel Garcia Marquez’s 1985 book of that name. X is usually something with a society-crossing effect, like global warming, insurgency, affluenza, the apocalypse, and of course, these days, COVID-19 or corona, which has overtaken all variations.
This snowclone naturally exists in Spanish as well: variations of X include redes (networks), Castro, corona (just as in English), impuestos.
The Snowclones Database 